SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

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Mol Cell Biol. 1988 January; 8(1): 466-472

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

Y Takebe, M Seiki, J Fujisawa, P Hoy, K Yokota, K Arai, M Yoshida and N Arai

Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California 94304.

ABSTRACT

We developed a novel promoter system, designated SR alpha, whichis composed of the simian virus 40 (SV40) early promoter andthe R segment and part of the U5 sequence (R-U5') of the longterminal repeat of human T-cell leukemia virus type 1. The R-U5'sequence stimulated chloramphenicol acetyltransferase (CAT)gene expression only when placed immediately downstream of theSV40 early promoter in the sense orientation. The SR alpha expressionsystem was 1 or 2 orders of magnitude more active than the SV40early promoter in a wide variety of cell types, including fibroblastsand lymphoid cells, and was capable of promoting a high levelof expression of various lymphokine cDNAs. These features ofthe SR alpha promoter were incorporated into the pcD-cDNA expressioncloning vector originally developed by Okayama and Berg.

Mol Cell Biol. 1988 January; 8(1): 466-472

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Kawaguchi, Y., Nakajima, K., Igarashi, M., Morita, T., Tanaka, M., Suzuki, M., Yokoyama, A., Matsuda, G., Kato, K., Kanamori, M., Hirai, K. (2000). Interaction of Epstein-Barr Virus Nuclear Antigen Leader Protein (EBNA-LP) with HS1-Associated Protein X-1: Implication of Cytoplasmic Function of EBNA-LP. J. Virol. 74: 10104-10111 [Abstract] [Full Text]
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