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Mol Cell Biol. 1985 December; 5(12): 3617-3620

Transforming activity of DNA fragments from normal human lymphocytes results from spontaneous activation of a c-Ha-ras1 gene.

R Schäfer, S Griegel, I Schwarte, S Geisse, O Traub and K Willecke

ABSTRACT

An activated human Ha-ras gene was present in a secondary NIH 3T3 transformant isolated after serial transfection of originally low-molecular-weight DNA fragments from normal human cells. This gene appeared to have acquired its transforming properties by a spontaneous mutation in codon 12 by substitution of a deoxythymidine residue for a deoxyguanosine residue. DNA rearrangements in the flanking sequences of the transferred Ha-ras gene were not involved in the activation of the protooncogene.

Mol Cell Biol. 1985 December; 5(12): 3617-3620






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