This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Raingeaud, J.
Right arrow Articles by Davis, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Raingeaud, J.
Right arrow Articles by Davis, R. J.

 Previous Article  |  Next Article 

Mol. Cell. Biol., 03 1996, 1247-1255, Vol 16, No. 3
Copyright © 1996, American Society for Microbiology

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen- activated protein kinase signal transduction pathway

J Raingeaud, AJ Whitmarsh, T Barrett, B Derijard and RJ Davis
Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605 USA.

The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by proinflammatory cytokines and environmental stress. The detection of p38 MAP kinase in the nucleus of activated cells suggests that p38 MAP kinase can mediate signaling to the nucleus. To test this hypothesis, we constructed expression vectors for activated MKK3 and MKK6, two MAP kinase kinases that phosphorylate and activate p38 MAP kinase. Expression of activated MKK3 and MKK6 in cultured cells caused a selective increase in p38 MAP kinase activity. Cotransfection experiments demonstrated that p38 MAP kinase activation causes increased reporter gene expression mediated by the transcription factors ATF2 and Elk-1. These data demonstrate that the nucleus is one target of the p38 MAP kinase signal transduction pathway.


This article has been cited by other articles:

  • Rodriguez-Garcia, M. E., Quiroga, A. G., Castro, J., Ortiz, A., Aller, P., Mata, F. (2009). Inhibition of p38-MAPK Potentiates Cisplatin-Induced Apoptosis via GSH Depletion and Increases Intracellular Drug Accumulation in Growth-Arrested Kidney Tubular Epithelial Cells. Toxicol Sci 111: 413-423 [Abstract] [Full Text]  
  • Jin, K., Ewton, D. Z., Park, S., Hu, J., Friedman, E. (2009). Mirk Regulates the Exit of Colon Cancer Cells from Quiescence. J. Biol. Chem. 284: 22916-22925 [Abstract] [Full Text]  
  • Xu, L., Ding, Y., Catalona, W. J., Yang, X. J., Anderson, W. F., Jovanovic, B., Wellman, K., Killmer, J., Huang, X., Scheidt, K. A., Montgomery, R. B., Bergan, R. C. (2009). MEK4 Function, Genistein Treatment, and Invasion of Human Prostate Cancer Cells. JNCI J Natl Cancer Inst 101: 1141-1155 [Abstract] [Full Text]  
  • Marchant, D., Dou, Y., Luo, H., Garmaroudi, F. S., McDonough, J. E., Si, X., Walker, E., Luo, Z., Arner, A., Hegele, R. G., Laher, I., McManus, B. M. (2009). Bosentan Enhances Viral Load via Endothelin-1 Receptor Type-A-Mediated p38 Mitogen-Activated Protein Kinase Activation While Improving Cardiac Function During Coxsackievirus-Induced Myocarditis. Circ. Res. 104: 813-821 [Abstract] [Full Text]  
  • Fan, S., Meng, Q., Laterra, J. J., Rosen, E. M. (2009). Role of Src Signal Transduction Pathways in Scatter Factor-mediated Cellular Protection. J. Biol. Chem. 284: 7561-7577 [Abstract] [Full Text]  
  • Kino, T., Takatori, H., Manoli, I., Wang, Y., Tiulpakov, A., Blackman, M. R., Su, Y. A., Chrousos, G. P., DeCherney, A. H., Segars, J. H. (2009). Brx Mediates the Response of Lymphocytes to Osmotic Stress Through the Activation of NFAT5. Sci Signal 2: ra5-ra5 [Abstract] [Full Text]  
  • Carrozzino, F., Pugnale, P., Feraille, E., Montesano, R. (2009). Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression. Am. J. Physiol. Cell Physiol. 297: C775-C787 [Abstract] [Full Text]  
  • Iwai, T., Murai, J., Yoshikawa, H., Tsumaki, N. (2008). Smad7 Inhibits Chondrocyte Differentiation at Multiple Steps during Endochondral Bone Formation and Down-regulates p38 MAPK Pathways. J. Biol. Chem. 283: 27154-27164 [Abstract] [Full Text]  
  • Fernandes, A. F., Zhou, J., Zhang, X., Bian, Q., Sparrow, J., Taylor, A., Pereira, P., Shang, F. (2008). Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UP-REGULATION OF INTERLEUKIN-8. J. Biol. Chem. 283: 20745-20753 [Abstract] [Full Text]  
  • Sheridan, D. L., Kong, Y., Parker, S. A., Dalby, K. N., Turk, B. E. (2008). Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs. J. Biol. Chem. 283: 19511-19520 [Abstract] [Full Text]  
  • Abidi, P., Zhang, H., Zaidi, S. M, Shen, W.-J., Leers-Sucheta, S., Cortez, Y., Han, J., Azhar, S. (2008). Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway. J Endocrinol 198: 193-207 [Abstract] [Full Text]  
  • Tephly, L. A., Carter, A. B. (2008). Asbestos-Induced MKP-3 Expression Augments TNF-{alpha} Gene Expression in Human Monocytes. Am. J. Respir. Cell Mol. Bio. 39: 113-123 [Abstract] [Full Text]  
  • Tang, G., Yue, Z., Talloczy, Z., Hagemann, T., Cho, W., Messing, A., Sulzer, D. L., Goldman, J. E. (2008). Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Hum Mol Genet 17: 1540-1555 [Abstract] [Full Text]  
  • Ramachandran, B., Yu, G., Li, S., Zhu, B., Gulick, T. (2008). Myocyte Enhancer Factor 2A Is Transcriptionally Autoregulated. J. Biol. Chem. 283: 10318-10329 [Abstract] [Full Text]  
  • Escors, D., Lopes, L., Lin, R., Hiscott, J., Akira, S., Davis, R. J., Collins, M. K. (2008). Targeting dendritic cell signaling to regulate the response to immunization. Blood 111: 3050-3061 [Abstract] [Full Text]  
  • Blagoveshchenskaya, A., Cheong, F. Y., Rohde, H. M., Glover, G., Knodler, A., Nicolson, T., Boehmelt, G., Mayinger, P. (2008). Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. JCB 180: 803-812 [Abstract] [Full Text]  
  • Wang, X., Nadarajah, B., Robinson, A. C., McColl, B. W., Jin, J.-W., Dajas-Bailador, F., Boot-Handford, R. P., Tournier, C. (2007). Targeted Deletion of the Mitogen-Activated Protein Kinase Kinase 4 Gene in the Nervous System Causes Severe Brain Developmental Defects and Premature Death. Mol. Cell. Biol. 27: 7935-7946 [Abstract] [Full Text]  
  • Cao, L., Yu, K., Banh, C., Nguyen, V., Ritz, A., Raphael, B. J., Kawakami, Y., Kawakami, T., Salomon, A. R. (2007). Quantitative Time-Resolved Phosphoproteomic Analysis of Mast Cell Signaling. J. Immunol. 179: 5864-5876 [Abstract] [Full Text]  
  • Chen, D., Reierstad, S., Lin, Z., Lu, M., Brooks, C., Li, N., Innes, J., Bulun, S. E. (2007). Prostaglandin E2 Induces Breast Cancer Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts. Cancer Res. 67: 8914-8922 [Abstract] [Full Text]  
  • Riuzzi, F., Sorci, G., Donato, R. (2007). RAGE Expression in Rhabdomyosarcoma Cells Results in Myogenic Differentiation and Reduced Proliferation, Migration, Invasiveness, and Tumor Growth. Am. J. Pathol. 171: 947-961 [Abstract] [Full Text]  
  • Kelley, M. J., Rose, A., Song, K., Lystrup, B., Samples, J. W., Acott, T. S. (2007). p38 MAP Kinase Pathway and Stromelysin Regulation in Trabecular Meshwork Cells. IOVS 48: 3126-3137 [Abstract] [Full Text]  
  • Kramer, H. F., Goodyear, L. J. (2007). Exercise, MAPK, and NF-{kappa}B signaling in skeletal muscle. J. Appl. Physiol. 103: 388-395 [Abstract] [Full Text]  
  • Woll, S., Windoffer, R., Leube, R. E. (2007). p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells. JCB 177: 795-807 [Abstract] [Full Text]  
  • Alford, K. A., Glennie, S., Turrell, B. R., Rawlinson, L., Saklatvala, J., Dean, J. L. E. (2007). Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-beta-activated Kinase-1 (TAK1)-mediated Signaling. J. Biol. Chem. 282: 6232-6241 [Abstract] [Full Text]  
  • Thusberg, J., Vihinen, M. (2007). The structural basis of hyper IgM deficiency - CD40L mutations. Protein Eng Des Sel 20: 133-141 [Abstract] [Full Text]  
  • Park, J.-K., Fischer, R., Dechend, R., Shagdarsuren, E., Gapeljuk, A., Wellner, M., Meiners, S., Gratze, P., Al-Saadi, N., Feldt, S., Fiebeler, A., Madwed, J. B., Schirdewan, A., Haller, H., Luft, F. C., Muller, D. N. (2007). p38 Mitogen-Activated Protein Kinase Inhibition Ameliorates Angiotensin II-Induced Target Organ Damage. Hypertension 49: 481-489 [Abstract] [Full Text]  
  • Askari, N., Diskin, R., Avitzour, M., Capone, R., Livnah, O., Engelberg, D. (2007). Hyperactive Variants of p38{alpha} Induce, whereas Hyperactive Variants of p38{gamma} Suppress, Activating Protein 1-mediated Transcription. J. Biol. Chem. 282: 91-99 [Abstract] [Full Text]  
  • Yuan-chen Wu, D., Wu, R., Reddy, S. P., Lee, Y. C., Chang, M. M.-J. (2007). Distinctive Epidermal Growth Factor Receptor/Extracellular Regulated Kinase-Independent and -Dependent Signaling Pathways in the Induction of Airway Mucin 5B and Mucin 5AC Expression by Phorbol 12-Myristate 13-Acetate. Am. J. Pathol. 170: 20-32 [Abstract] [Full Text]  
  • Wattenberg, E. V. (2007). Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis. Am. J. Physiol. Cell Physiol. 292: C24-C32 [Abstract] [Full Text]  
  • Garcia, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., Esteban, M. (2006). Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action. Microbiol. Mol. Biol. Rev. 70: 1032-1060 [Abstract] [Full Text]  
  • Zhang, X., Kim, J., Ruthazer, R., McDevitt, M. A., Wazer, D. E., Paulson, K. E., Yee, A. S. (2006). The HBP1 Transcriptional Repressor Participates in RAS-Induced Premature Senescence. Mol. Cell. Biol. 26: 8252-8266 [Abstract] [Full Text]  
  • Lu, Z., Serghides, L., Patel, S. N., Degousee, N., Rubin, B. B., Krishnegowda, G., Gowda, D. C., Karin, M., Kain, K. C. (2006). Disruption of JNK2 Decreases the Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol In Vitro and Confers Protection in a Cerebral Malaria Model. J. Immunol. 177: 6344-6352 [Abstract] [Full Text]  
  • Toh, M.-L., Aeberli, D., Lacey, D., Yang, Y., Santos, L. L., Clarkson, M., Sharma, L., Clyne, C., Morand, E. F. (2006). Regulation of IL-1 and TNF Receptor Expression and Function by Endogenous Macrophage Migration Inhibitory Factor. J. Immunol. 177: 4818-4825 [Abstract] [Full Text]  
  • Sato, S., Sanjo, H., Tsujimura, T., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., Takeuchi, O., Akira, S. (2006). TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol 18: 1405-1411 [Abstract] [Full Text]  
  • Keum, Y.-S., Yu, S., Chang, P. P.-J., Yuan, X., Kim, J.-H., Xu, C., Han, J., Agarwal, A., Kong, A.-N. T. (2006). Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element-Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells.. Cancer Res. 66: 8804-8813 [Abstract] [Full Text]  
  • Lin, T. H., Metzger, A., Diller, D. J., Desai, M., Henderson, I., Ahmed, G., Kimble, E. F., Quadros, E., Webb, M. L. (2006). Discovery and Characterization of Triaminotriazine Aniline Amides as Highly Selective p38 Kinase Inhibitors. J. Pharmacol. Exp. Ther. 318: 495-502 [Abstract] [Full Text]  
  • Rishi, A. K., Zhang, L., Yu, Y., Jiang, Y., Nautiyal, J., Wali, A., Fontana, J. A., Levi, E., Majumdar, A. P. N. (2006). Cell Cycle- and Apoptosis-regulatory Protein-1 Is Involved in Apoptosis Signaling by Epidermal Growth Factor Receptor. J. Biol. Chem. 281: 13188-13198 [Abstract] [Full Text]  
  • Niwano, K., Arai, M., Koitabashi, N., Hara, S., Watanabe, A., Sekiguchi, K., Tanaka, T., Iso, T., Kurabayashi, M. (2006). Competitive Binding of CREB and ATF2 to cAMP/ATF Responsive Element Regulates eNOS Gene Expression in Endothelial Cells. Arterioscler. Thromb. Vasc. Bio. 26: 1036-1042 [Abstract] [Full Text]  
  • Inoue, T., Boyle, D. L., Corr, M., Hammaker, D., Davis, R. J., Flavell, R. A., Firestein, G. S. (2006). Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc. Natl. Acad. Sci. USA 103: 5484-5489 [Abstract] [Full Text]  
  • Ryter, S. W., Alam, J., Choi, A. M. K. (2006). Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications. Physiol. Rev. 86: 583-650 [Abstract] [Full Text]  
  • Wang, X. M., Kim, H. P., Song, R., Choi, A. M. K. (2006). Caveolin-1 Confers Antiinflammatory Effects in Murine Macrophages via the MKK3/p38 MAPK Pathway. Am. J. Respir. Cell Mol. Bio. 34: 434-442 [Abstract] [Full Text]  
  • Farley, N., Pedraza-Alva, G., Serrano-Gomez, D., Nagaleekar, V., Aronshtam, A., Krahl, T., Thornton, T., Rincon, M. (2006). p38 Mitogen-Activated Protein Kinase Mediates the Fas-Induced Mitochondrial Death Pathway in CD8+ T Cells.. Mol. Cell. Biol. 26: 2118-2129 [Abstract] [Full Text]  
  • Birrell, M. A., Wong, S., McCluskie, K., Catley, M. C., Hardaker, E. L., Haj-Yahia, S., Belvisi, M. G. (2006). Second-Generation Inhibitors Demonstrate the Involvement of p38 Mitogen-Activated Protein Kinase in Post-Transcriptional Modulation of Inflammatory Mediator Production in Human and Rodent Airways. J. Pharmacol. Exp. Ther. 316: 1318-1327 [Abstract] [Full Text]  
  • O'Hayre, M., Taylor, L., Andratsch, M., Feifel, E., Gstraunthaler, G., Curthoys, N. P. (2006). Effects of Constitutively Active and Dominant Negative MAPK Kinase (MKK) 3 and MKK6 on the pH-responsive Increase in Phosphoenolpyruvate Carboxykinase mRNA. J. Biol. Chem. 281: 2982-2988 [Abstract] [Full Text]  
  • Hsieh, C.-C., Papaconstantinou, J. (2006). Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice. FASEB J. 20: 259-268 [Abstract] [Full Text]  
  • Zhang, H., Liu, H., Iles, K. E., Liu, R.-M., Postlethwait, E. M., Laperche, Y., Forman, H. J. (2006). 4-Hydroxynonenal Induces Rat {gamma}-Glutamyl Transpeptidase through Mitogen-Activated Protein Kinase-Mediated Electrophile Response Element/Nuclear Factor Erythroid 2-Related Factor 2 Signaling. Am. J. Respir. Cell Mol. Bio. 34: 174-181 [Abstract] [Full Text]  
  • Zhao, Q., Wang, X., Nelin, L. D., Yao, Y., Matta, R., Manson, M. E., Baliga, R. S., Meng, X., Smith, C. V., Bauer, J. A., Chang, C.-H., Liu, Y. (2006). MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. JEM 203: 131-140 [Abstract] [Full Text]  
  • Fu, J., Yang, Z., Wei, J., Han, J., Gu, J. (2006). Nuclear protein NP60 regulates p38 MAPK activity. J. Cell Sci. 119: 115-123 [Abstract] [Full Text]  
  • Bradham, C. A., McClay, D. R. (2006). p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos. Development 133: 21-32 [Abstract] [Full Text]  
  • Jin, K., Lim, S., Mercer, S. E., Friedman, E. (2005). The Survival Kinase Mirk/dyrk1B Is Activated through Rac1-MKK3 Signaling. J. Biol. Chem. 280: 42097-42105 [Abstract] [Full Text]  
  • Si, X., Luo, H., Morgan, A., Zhang, J., Wong, J., Yuan, J., Esfandiarei, M., Gao, G., Cheung, C., McManus, B. M. (2005). Stress-Activated Protein Kinases Are Involved in Coxsackievirus B3 Viral Progeny Release. J. Virol. 79: 13875-13881 [Abstract] [Full Text]  
  • Fan, J., Heller, N. M., Gorospe, M., Atasoy, U., Stellato, C. (2005). The role of post-transcriptional regulation in chemokine gene expression in inflammation and allergy. Eur Respir J 26: 933-947 [Abstract] [Full Text]  
  • Wang, H., Gupta, D., Li, X., Dziarski, R. (2005). Peptidoglycan Recognition Protein 2 (N-Acetylmuramoyl-L-Ala Amidase) Is Induced in Keratinocytes by Bacteria through the p38 Kinase Pathway. Infect. Immun. 73: 7216-7225 [Abstract] [Full Text]  
  • Contestabile, A., Fila, T., Bartesaghi, R., Ciani, E. (2005). Cyclic AMP-mediated Regulation of Transcription Factor Lot1 Expression in Cerebellar Granule Cells. J. Biol. Chem. 280: 33541-33551 [Abstract] [Full Text]  
  • Yoshizuka, N., Yoshizuka-Chadani, Y., Krishnan, V., Zeichner, S. L. (2005). Human Immunodeficiency Virus Type 1 Vpr-Dependent Cell Cycle Arrest through a Mitogen-Activated Protein Kinase Signal Transduction Pathway. J. Virol. 79: 11366-11381 [Abstract] [Full Text]  
  • Boureux, A., Furstoss, O., Simon, V., Roche, S. (2005). Abl tyrosine kinase regulates a Rac/JNK and a Rac/Nox pathway for DNA synthesis and Myc expression induced by growth factors. J. Cell Sci. 118: 3717-3726 [Abstract] [Full Text]  
  • Robidoux, J., Cao, W., Quan, H., Daniel, K. W., Moukdar, F., Bai, X., Floering, L. M., Collins, S. (2005). Selective Activation of Mitogen-Activated Protein (MAP) Kinase Kinase 3 and p38{alpha} MAP Kinase Is Essential for Cyclic AMP-Dependent UCP1 Expression in Adipocytes. Mol. Cell. Biol. 25: 5466-5479 [Abstract] [Full Text]  
  • Emerling, B. M., Platanias, L. C., Black, E., Nebreda, A. R., Davis, R. J., Chandel, N. S. (2005). Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling. Mol. Cell. Biol. 25: 4853-4862 [Abstract] [Full Text]  
  • Akimoto, T., Pohnert, S. C., Li, P., Zhang, M., Gumbs, C., Rosenberg, P. B., Williams, R. S., Yan, Z. (2005). Exercise Stimulates Pgc-1{alpha} Transcription in Skeletal Muscle through Activation of the p38 MAPK Pathway. J. Biol. Chem. 280: 19587-19593 [Abstract] [Full Text]  
  • Kayahara, M., Wang, X., Tournier, C. (2005). Selective Regulation of c-jun Gene Expression by Mitogen-Activated Protein Kinases via the 12-O-Tetradecanoylphorbol-13-Acetate- Responsive Element and Myocyte Enhancer Factor 2 Binding Sites. Mol. Cell. Biol. 25: 3784-3792 [Abstract] [Full Text]  
  • Zhu, M., Granillo, O., Wen, R., Yang, K., Dai, X., Wang, D., Zhang, W. (2005). Negative Regulation of Lymphocyte Activation by the Adaptor Protein LAX. J. Immunol. 174: 5612-5619 [Abstract] [Full Text]  
  • Qiao, B., Padilla, S. R., Benya, P. D. (2005). Transforming Growth Factor (TGF)-{beta}-activated Kinase 1 Mimics and Mediates TGF-{beta}-induced Stimulation of Type II Collagen Synthesis in Chondrocytes Independent of Col2a1 Transcription and Smad3 Signaling. J. Biol. Chem. 280: 17562-17571 [Abstract] [Full Text]  
  • Simoncini, S., Sapet, C., Camoin-Jau, L., Bardin, N., Harle, J.-R., Sampol, J., Dignat-George, F., Anfosso, F. (2005). Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome. Int Immunol 17: 489-500 [Abstract] [Full Text]  
  • Kim, L., Rio, L. D., Butcher, B. A., Mogensen, T. H., Paludan, S. R., Flavell, R. A., Denkers, E. Y. (2005). p38 MAPK Autophosphorylation Drives Macrophage IL-12 Production during Intracellular Infection. J. Immunol. 174: 4178-4184 [Abstract] [Full Text]  
  • Inoue, T., Hammaker, D., Boyle, D. L., Firestein, G. S. (2005). Regulation of p38 MAPK by MAPK Kinases 3 and 6 in Fibroblast-Like Synoviocytes. J. Immunol. 174: 4301-4306 [Abstract] [Full Text]  
  • Li, Y., Batra, S., Sassano, A., Majchrzak, B., Levy, D. E., Gaestel, M., Fish, E. N., Davis, R. J., Platanias, L. C. (2005). Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons. J. Biol. Chem. 280: 10001-10010 [Abstract] [Full Text]  
  • Singhirunnusorn, P., Suzuki, S., Kawasaki, N., Saiki, I., Sakurai, H. (2005). Critical Roles of Threonine 187 Phosphorylation in Cellular Stress-induced Rapid and Transient Activation of Transforming Growth Factor-{beta}-activated Kinase 1 (TAK1) in a Signaling Complex Containing TAK1-binding Protein TAB1 and TAB2. J. Biol. Chem. 280: 7359-7368 [Abstract] [Full Text]  
  • Kaur, R., Liu, X., Gjoerup, O., Zhang, A., Yuan, X., Balk, S. P., Schneider, M. C., Lu, M. L. (2005). Activation of p21-activated Kinase 6 by MAP Kinase Kinase 6 and p38 MAP Kinase. J. Biol. Chem. 280: 3323-3330 [Abstract] [Full Text]  
  • Bailey, J., Europe-Finner, G N. (2005). Identification of human myometrial target genes of the c-Jun NH2-terminal kinase (JNK) pathway: the role of activating transcription factor 2 (ATF2) and a novel spliced isoform ATF2-small. J Mol Endocrinol 34: 19-35 [Abstract] [Full Text]  
  • Lewis, J. S, Thomas, T J, Pestell, R. G, Albanese, C., Gallo, M. A, Thomas, T. (2005). Differential effects of 16{alpha}-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. J Mol Endocrinol 34: 91-105 [Abstract] [Full Text]  
  • Yang, T. T. C., Xiong, Q., Graef, I. A., Crabtree, G. R., Chow, C.-W. (2005). Recruitment of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Signaling Pathway to the NFATc4 Transcription Activation Complex. Mol. Cell. Biol. 25: 907-920 [Abstract] [Full Text]  
  • Bustamante, M., Hasler, U., Kotova, O., Chibalin, A. V., Mordasini, D., Rousselot, M., Vandewalle, A., Martin, P.-Y., Feraille, E. (2005). Insulin potentiates AVP-induced AQP2 expression in cultured renal collecting duct principal cells. Am. J. Physiol. Renal Physiol. 288: F334-F344 [Abstract] [Full Text]  
  • Albig, A. R., Schiemann, W. P. (2005). Identification and Characterization of Regulator of G Protein Signaling 4 (RGS4) as a Novel Inhibitor of Tubulogenesis: RGS4 Inhibits Mitogen-activated Protein Kinases and Vascular Endothelial Growth Factor Signaling. Mol. Biol. Cell 16: 609-625 [Abstract] [Full Text]  
  • Perfettini, J.-L., Castedo, M., Nardacci, R., Ciccosanti, F., Boya, P., Roumier, T., Larochette, N., Piacentini, M., Kroemer, G. (2005). Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope. JEM 201: 279-289 [Abstract] [Full Text]  
  • Slice, L. W., Chiu, T., Rozengurt, E. (2005). Angiotensin II and Epidermal Growth Factor Induce Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Small GTPases Using Distinct Signaling Pathways. J. Biol. Chem. 280: 1582-1593 [Abstract] [Full Text]  
  • Campbell, J., Ciesielski, C. J., Hunt, A. E., Horwood, N. J., Beech, J. T., Hayes, L. A., Denys, A., Feldmann, M., Brennan, F. M., Foxwell, B. M. J. (2004). A Novel Mechanism for TNF-{alpha} Regulation by p38 MAPK: Involvement of NF-{kappa}B with Implications for Therapy in Rheumatoid Arthritis. J. Immunol. 173: 6928-6937 [Abstract] [Full Text]  
  • Tan, Z., Huang, M., Puga, A., Xia, Y. (2004). A Critical Role For MAP Kinases in the Control of Ah Receptor Complex Activity. Toxicol Sci 82: 80-87 [Abstract] [Full Text]  
  • Abdelli, S., Ansite, J., Roduit, R., Borsello, T., Matsumoto, I., Sawada, T., Allaman-Pillet, N., Henry, H., Beckmann, J. S., Hering, B. J., Bonny, C. (2004). Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure. Diabetes 53: 2815-2823 [Abstract] [Full Text]  
  • Chik, C. L., Mackova, M., Price, D., Ho, A. K. (2004). Adrenergic Regulation and Diurnal Rhythm of p38 Mitogen-Activated Protein Kinase Phosphorylation in the Rat Pineal Gland. Endocrinology 145: 5194-5201 [Abstract] [Full Text]  
  • Szatmary, Z., Garabedian, M. J., Vilcek, J. (2004). Inhibition of Glucocorticoid Receptor-mediated Transcriptional Activation by p38 Mitogen-activated Protein (MAP) Kinase. J. Biol. Chem. 279: 43708-43715 [Abstract] [Full Text]  
  • Liu, C., Russell, R. M., Wang, X.-D. (2004). Low Dose {beta}-Carotene Supplementation of Ferrets Attenuates Smoke-Induced Lung Phosphorylation of JNK, p38 MAPK, and p53 Proteins. J. Nutr. 134: 2705-2710 [Abstract] [Full Text]  
  • Shin, J., Park, B., Cho, S., Lee, S., Kim, Y., Lee, S.-O., Cho, K., Lee, S., Jin, B.-S., Ahn, J.-H., Choi, E.-J., Ahn, K. (2004). Promyelocytic Leukemia Is a Direct Inhibitor of SAPK2/p38 Mitogen-activated Protein Kinase. J. Biol. Chem. 279: 40994-41003 [Abstract] [Full Text]  
  • Zhu, B., Gulick, T. (2004). Phosphorylation and Alternative Pre-mRNA Splicing Converge To Regulate Myocyte Enhancer Factor 2C Activity. Mol. Cell. Biol. 24: 8264-8275 [Abstract] [Full Text]  
  • Silva, A. M., Whitmore, M., Xu, Z., Jiang, Z., Li, X., Williams, B. R. G. (2004). Protein Kinase R (PKR) Interacts with and Activates Mitogen-activated Protein Kinase Kinase 6 (MKK6) in Response to Double-stranded RNA Stimulation. J. Biol. Chem. 279: 37670-37676 [Abstract] [Full Text]  
  • Mukhopadhyay, S., Munshi, H. G., Kambhampati, S., Sassano, A., Platanias, L. C., Stack, M. S. (2004). Calcium-induced Matrix Metalloproteinase 9 Gene Expression Is Differentially Regulated by ERK1/2 and p38 MAPK in Oral Keratinocytes and Oral Squamous Cell Carcinoma. J. Biol. Chem. 279: 33139-33146 [Abstract] [Full Text]  
  • Huntington, J. T., Shields, J. M., Der, C. J., Wyatt, C. A., Benbow, U., Slingluff, C. L. Jr., Brinckerhoff, C. E. (2004). Overexpression of Collagenase 1 (MMP-1) Is Mediated by the ERK Pathway in Invasive Melanoma Cells: ROLE OF BRAF MUTATION AND FIBROBLAST GROWTH FACTOR SIGNALING. J. Biol. Chem. 279: 33168-33176 [Abstract] [Full Text]  
  • Wang, L., Kwak, J. H., Kim, S. I., He, Y., Choi, M. E. (2004). Transforming Growth Factor-{beta}1 Stimulates Vascular Endothelial Growth Factor 164 via Mitogen-activated Protein Kinase Kinase 3-p38{alpha} and p38{delta} Mitogen-activated Protein Kinase-dependent Pathway in Murine Mesangial Cells. J. Biol. Chem. 279: 33213-33219 [Abstract] [Full Text]  
  • Villa-Diaz, L. G., Miyano, T. (2004). Activation of p38 MAPK During Porcine Oocyte Maturation. Biol. Reprod. 71: 691-696 [Abstract] [Full Text]  
  • Kim, D. H., Liberati, N. T., Mizuno, T., Inoue, H., Hisamoto, N., Matsumoto, K., Ausubel, F. M. (2004). From the Cover: Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc. Natl. Acad. Sci. USA 101: 10990-10994 [Abstract] [Full Text]  
  • Qi, X., Tang, J., Pramanik, R., Schultz, R. M., Shirasawa, S., Sasazuki, T., Han, J., Chen, G. (2004). p38 MAPK Activation Selectively Induces Cell Death in K-ras-mutated Human Colon Cancer Cells through Regulation of Vitamin D Receptor. J. Biol. Chem. 279: 22138-22144 [Abstract] [Full Text]  
  • Powell, C. S., Wright, M. M., Jackson, R. M. (2004). p38mapk and MEK1/2 inhibition contribute to cellular oxidant injury after hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L826-L833 [Abstract] [Full Text]  
  • Tikhomirov, O., Carpenter, G. (2004). Ligand-induced, p38-dependent Apoptosis in Cells Expressing High Levels of Epidermal Growth Factor Receptor and ErbB-2. J. Biol. Chem. 279: 12988-12996 [Abstract] [Full Text]  
  • Papakrivopoulou, J., Lindahl, G. E, Bishop, J. E, Laurent, G. J (2004). Differential roles of extracellular signal-regulated kinase 1/2 and p38MAPK in mechanical load-induced procollagen {alpha}1(I) gene expression in cardiac fibroblasts. Cardiovasc Res 61: 736-744 [Abstract] [Full Text]  
  • Park, J. S., Svetkauskaite, D., He, Q., Kim, J.-Y., Strassheim, D., Ishizaka, A., Abraham, E. (2004). Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein. J. Biol. Chem. 279: 7370-7377 [Abstract] [Full Text]  
  • Stambe, C., Nikolic-Paterson, D. J., Hill, P. A., Dowling, J., Atkins, R. C. (2004). p38 Mitogen-Activated Protein Kinase Activation and Cell Localization in Human Glomerulonephritis: Correlation with Renal Injury. J. Am. Soc. Nephrol. 15: 326-336 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»