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Mol. Cell. Biol., May 1995, 2809-2818, Vol 15, No. 5
Copyright © 1995, American Society for Microbiology

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

JA Brockman, DC Scherer, TA McKinsey, SM Hall, X Qi, WY Lee and DW Ballard
Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0295, USA.

The eukaryotic transcription factor NF-kappa B plays a central role in the induced expression of human immunodeficiency virus type 1 and in many aspects of the genetic program mediating normal T-cell activation and growth. The nuclear activity of NF-kappa B is tightly regulated from the cytoplasmic compartment by an inhibitory subunit called I kappa B alpha. This cytoplasmic inhibitor is rapidly phosphorylated and degraded in response to a diverse set of NF-kappa B-inducing agents, including T-cell mitogens, proinflammatory cytokines, and viral transactivators such as the Tax protein of human T-cell leukemia virus type 1. To explore these I kappa B alpha-dependent mechanisms for NF- kappa B induction, we identified novel mutants of I kappa B alpha that uncouple its inhibitory and signal-transducing functions in human T lymphocytes. Specifically, removal of the N-terminal 36 amino acids of I kappa B alpha failed to disrupt its ability to form latent complexes with NF-kappa B in the cytoplasm. However, this deletion mutation prevented the induced phosphorylation, degradative loss, and functional release of I kappa B alpha from NF-kappa B in Tax-expressing cells. Alanine substitutions introduced at two serine residues positioned within this N-terminal regulatory region of I kappa B alpha also yielded constitutive repressors that escaped from Tax-induced turnover and that potently inhibited immune activation pathways for NF-kappa B induction, including those initiated from antigen and cytokine receptors. In contrast, introduction of a phosphoserine mimetic at these sites rectified this functional defect, a finding consistent with a causal linkage between the phosphorylation status and proteolytic stability of this cytoplasmic inhibitor. Together, these in vivo studies define a critical signal response domain in I kappa B alpha that coordinately controls the biologic activities of I kappa B alpha and NF-kappa B in response to viral and immune stimuli.


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  • Mora, A. L., Stanley, S., Armistead, W., Chan, A. C., Boothby, M. (2001). Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-{kappa}B/Rel. J. Immunol. 167: 5628-5635 [Abstract] [Full Text]  
  • Bradbury, C. M., Markovina, S., Wei, S. J., Rene, L. M., Zoberi, I., Horikoshi, N., Gius, D. (2001). Indomethacin-induced Radiosensitization and Inhibition of Ionizing Radiation-induced NF-{kappa}B Activation in HeLa Cells Occur via a Mechanism Involving p38 MAP Kinase. Cancer Res. 61: 7689-7696 [Abstract] [Full Text]  
  • Liao, C.-L., Lin, Y.-L., Wu, B.-C., Tsao, C.-H., Wang, M.-C., Liu, C.-I, Huang, Y.-L., Chen, J.-H., Wang, J.-P., Chen, L.-K. (2001). Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation. J. Virol. 75: 7828-7839 [Abstract] [Full Text]  
  • Laurent, G., Jaffrezou, J.-P. (2001). Signaling pathways activated by daunorubicin. Blood 98: 913-924 [Abstract] [Full Text]  
  • Fernandez, N. Q., Grosshans, J., Goltz, J. S., Stein, D. (2001). Separable and redundant regulatory determinants in Cactus mediate its dorsal group dependent degradation. Development 128: 2963-2974 [Abstract] [Full Text]  
  • Faruqi, T. R., Gomez, D., Bustelo, X. R., Bar-Sagi, D., Reich, N. C. (2001). Rac1 mediates STAT3 activation by autocrine IL-6. Proc. Natl. Acad. Sci. USA 10.1073/pnas.161281298v1 [Abstract] [Full Text]  
  • Shen, H., Chen, Z. J., Zilfou, J. T., Hopper, E., Murphy, M., Tew, K. D. (2001). Binding of the Aminothiol WR-1065 to Transcription Factors Influences Cellular Response to Anticancer Drugs. J. Pharmacol. Exp. Ther. 297: 1067-1073 [Abstract] [Full Text]  
  • Tu, Z., Kelley, V. R., Collins, T., Lee, F. S. (2001). I{{kappa}}B Kinase Is Critical for TNF-{{alpha}}-Induced VCAM1 Gene Expression in Renal Tubular Epithelial Cells. J. Immunol. 166: 6839-6846 [Abstract] [Full Text]  
  • Hay, D. C., Kemp, G. D., Dargemont, C., Hay, R. T. (2001). Interaction between hnRNPA1 and I{kappa}B{alpha} Is Required for Maximal Activation of NF-{kappa}B-Dependent Transcription. Mol. Cell. Biol. 21: 3482-3490 [Abstract] [Full Text]  
  • Wang, Q., Dziarski, R., Kirschning, C. J., Muzio, M., Gupta, D. (2001). Micrococci and Peptidoglycan Activate TLR2{right-arrow}MyD88{right-arrow}IRAK{right-arrow}TRAF{right-arrow}NIK{right-arrow}IKK{right-arrow}NF-{kappa}B Signal Transduction Pathway That Induces Transcription of Interleukin-8. Infect. Immun. 69: 2270-2276 [Abstract] [Full Text]  
  • Purcell, N. H., Yu, C., He, D., Xiang, J., Paran, N., DiDonato, J. A., Yamaoka, S., Shaul, Y., Lin, A. (2001). Activation of NF-{kappa}B by hepatitis B virus X protein through an I{kappa}B kinase-independent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G669-G677 [Abstract] [Full Text]  
  • Mori, N., Morishita, M., Tsukazaki, T., Giam, C.-Z., Kumatori, A., Tanaka, Y., Yamamoto, N. (2001). Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor {beta} signaling through interaction with CREB-binding protein/p300. Blood 97: 2137-2144 [Abstract] [Full Text]  
  • Mori, N., Ueda, A., Geleziunas, R., Wada, A., Hirayama, T., Yoshimura, T., Yamamoto, N. (2001). Induction of Monocyte Chemoattractant Protein 1 by Helicobacter pylori Involves NF-{kappa}B. Infect. Immun. 69: 1280-1286 [Abstract] [Full Text]  
  • Haudek, S. B., Spencer, E., Bryant, D. D., White, D. J., Maass, D., Horton, J. W., Chen, Z. J., Giroir, B. P. (2001). Overexpression of cardiac I-{kappa}B{alpha} prevents endotoxin-induced myocardial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 280: H962-H968 [Abstract] [Full Text]  
  • Bui, N. T., Livolsi, A., Peyron, J.-F., Prehn, J. H.M. (2001). Activation of Nuclear Factor {kappa}b and bcl-x Survival Gene Expression by Nerve Growth Factor Requires Tyrosine Phosphorylation of I{kappa}B{alpha}. JCB 152: 753-764 [Abstract] [Full Text]  
  • Mora, A. L., Youn, J., Keegan, A. D., Boothby, M. (2001). NF-{{kappa}}B/Rel Participation in the Lymphokine-Dependent Proliferation of T Lymphoid Cells. J. Immunol. 166: 2218-2227 [Abstract] [Full Text]  
  • Shinohara, T., Miki, T., Nishimura, N., Nokihara, H., Hamada, H., Mukaida, N., Sone, S. (2001). Nuclear Factor-{{kappa}}B-dependent Expression of Metastasis Suppressor KAI1/CD82 Gene in Lung Cancer Cell Lines Expressing Mutant p53. Cancer Res. 61: 673-678 [Abstract] [Full Text]  
  • Wang, X., Li, M., Zheng, H., Muster, T., Palese, P., Beg, A. A., García-Sastre, A. (2000). Influenza A Virus NS1 Protein Prevents Activation of NF-kappa B and Induction of Alpha/Beta Interferon. J. Virol. 74: 11566-11573 [Abstract] [Full Text]  
  • Yang, C. H., Murti, A., Pfeffer, S. R., Basu, L., Kim, J. G., Pfeffer, L. M. (2000). IFNalpha /beta promotes cell survival by activating NF-kappa B. Proc. Natl. Acad. Sci. USA 10.1073/pnas.250477397v1 [Abstract] [Full Text]  
  • Henry, D. O., Moskalenko, S. A., Kaur, K. J., Fu, M., Pestell, R. G., Camonis, J. H., White, M. A. (2000). Ral GTPases Contribute to Regulation of Cyclin D1 through Activation of NF-kappa B. Mol. Cell. Biol. 20: 8084-8092 [Abstract] [Full Text]  
  • Foehr, E. D., Lin, X., O'Mahony, A., Geleziunas, R., Bradshaw, R. A., Greene, W. C. (2000). NF-kappa B Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells. J. Neurosci. 20: 7556-7563 [Abstract] [Full Text]  


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