This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schaller, M D
Right arrow Articles by Parsons, J T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schaller, M D
Right arrow Articles by Parsons, J T

 Previous Article  |  Next Article 

Mol Cell Biol. 1994 March; 14(3): 1680-1688

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

M D Schaller, J D Hildebrand, J D Shannon, J W Fox, R R Vines and J T Parsons

Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908.

ABSTRACT

The phosphorylation of protein tyrosine kinases (PTKs) on tyrosine residues is a critical regulatory event that modulates catalytic activity and triggers the physical association of PTKs with Src homology 2 (SH2)-containing proteins. The integrin-linked focal adhesion kinase, pp125FAK, exhibits extracellular matrix-dependent phosphorylation on tyrosine and physically associates with two nonreceptor PTKs, pp60src and pp59fyn, via their SH2 domains. Herein, we identify Tyr-397 as the major site of tyrosine phosphorylation on pp125FAK both in vivo and in vitro. Tyrosine 397 is located at the juncture of the N-terminal and catalytic domains, a novel site for PTK autophosphorylation. Mutation of Tyr-397 to a nonphosphorylatable residue dramatically impairs the phosphorylation of pp125FAK on tyrosine in vivo and in vitro. The mutation of Tyr-397 to Phe also inhibits the formation of stable complexes with pp60src in cells expressing Src and FAK397F, suggesting that autophosphorylation of pp125FAK may regulate the association of pp125FAK with Src family kinases in vivo. The identification of Tyr-397 as a major site for FAK autophosphorylation provides one of the first examples of a cellular protein containing a high-affinity binding site for a Src family kinase SH2 domain. This finding has implications for models describing the mechanisms of action of pp125FAK, the regulation of the Src family of PTKs, and signal transduction through the integrins.

Mol Cell Biol. 1994 March; 14(3): 1680-1688




This article has been cited by other articles:

  • Peng, L., Ran, Y.-L., Hu, H., Yu, L., Liu, Q., Zhou, Z., Sun, Y.-M., Sun, L.-C., Pan, J., Sun, L.-X., Zhao, P., Yang, Z.-H. (2009). Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. Carcinogenesis 30: 1660-1669 [Abstract] [Full Text]  
  • Park, J. H., Han, H. J. (2009). Caveolin-1 plays important role in EGF-induced migration and proliferation of mouse embryonic stem cells: involvement of PI3K/Akt and ERK. Am. J. Physiol. Cell Physiol. 297: C935-C944 [Abstract] [Full Text]  
  • Shi, Y., Pontrello, C. G., DeFea, K. A., Reichardt, L. F., Ethell, I. M. (2009). Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity. J. Neurosci. 29: 8129-8142 [Abstract] [Full Text]  
  • Gupta, S. K., Vlahakis, N. E. (2009). Integrin {alpha}9{beta}1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase. J. Cell Sci. 122: 2043-2054 [Abstract] [Full Text]  
  • Liu, Z., Adams, H. C. III, Whitehead, I. P. (2009). The Rho-specific Guanine Nucleotide Exchange Factor Dbs Regulates Breast Cancer Cell Migration. J. Biol. Chem. 284: 15771-15780 [Abstract] [Full Text]  
  • Camara, J., Wang, Z., Nunes-Fonseca, C., Friedman, H. C., Grove, M., Sherman, D. L., Komiyama, N. H., Grant, S. G., Brophy, P. J., Peterson, A., ffrench-Constant, C. (2009). Integrin-mediated axoglial interactions initiate myelination in the central nervous system. JCB 185: 699-712 [Abstract] [Full Text]  
  • Michael, K. E., Dumbauld, D. W., Burns, K. L., Hanks, S. K., Garcia, A. J. (2009). Focal Adhesion Kinase Modulates Cell Adhesion Strengthening via Integrin Activation. Mol. Biol. Cell 20: 2508-2519 [Abstract] [Full Text]  
  • Chan, K. T., Cortesio, C. L., Huttenlocher, A. (2009). FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. JCB 185: 357-370 [Abstract] [Full Text]  
  • Skuli, N., Monferran, S., Delmas, C., Favre, G., Bonnet, J., Toulas, C., Cohen-Jonathan Moyal, E. (2009). {alpha}v{beta}3/{alpha}v{beta}5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma. Cancer Res. 69: 3308-3316 [Abstract] [Full Text]  
  • Waschbusch, D., Born, S., Niediek, V., Kirchgessner, N., Tamboli, I. Y., Walter, J., Merkel, R., Hoffmann, B. (2009). Presenilin 1 Affects Focal Adhesion Site Formation and Cell Force Generation via c-Src Transcriptional and Posttranslational Regulation. J. Biol. Chem. 284: 10138-10149 [Abstract] [Full Text]  
  • Huot, M.-E., Brown, C. M., Lamarche-Vane, N., Richard, S. (2009). An Adaptor Role for Cytoplasmic Sam68 in Modulating Src Activity during Cell Polarization. Mol. Cell. Biol. 29: 1933-1943 [Abstract] [Full Text]  
  • Papusheva, E., de Queiroz, F. M., Dalous, J., Han, Y., Esposito, A., Jares-Erijmanxa, E. A., Jovin, T. M., Bunt, G. (2009). Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility. J. Cell Sci. 122: 656-666 [Abstract] [Full Text]  
  • Milano, V., Piao, Y., LaFortune, T., de Groot, J. (2009). Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma. Molecular Cancer Therapeutics 8: 394-406 [Abstract] [Full Text]  
  • Chen, J., Lu, Y., Meng, S., Han, M.-H., Lin, C., Wang, X. (2009). {alpha}- and {gamma}-Protocadherins Negatively Regulate PYK2. J. Biol. Chem. 284: 2880-2890 [Abstract] [Full Text]  
  • Wei, W.-C., Lin, H.-H., Shen, M.-R., Tang, M.-J. (2008). Mechanosensing machinery for cells under low substratum rigidity. Am. J. Physiol. Cell Physiol. 295: C1579-C1589 [Abstract] [Full Text]  
  • Abouzahr-Rifai, S., Hasmim, M., Boukerche, H., Hamelin, J., Janji, B., Jalil, A., Kieda, C., Mami-Chouaib, F., Bertoglio, J., Chouaib, S. (2008). Resistance of Tumor Cells to Cytolytic T Lymphocytes Involves Rho-GTPases and Focal Adhesion Kinase Activation. J. Biol. Chem. 283: 31665-31672 [Abstract] [Full Text]  
  • Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Beggs, H. E., Keely, P. J. (2008). Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer. Am. J. Pathol. 173: 1551-1565 [Abstract] [Full Text]  
  • Boukerche, H., Su, Z.-z., Prevot, C., Sarkar, D., Fisher, P. B. (2008). mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src. Proc. Natl. Acad. Sci. USA 105: 15914-15919 [Abstract] [Full Text]  
  • Peng, X., Wu, X., Druso, J. E., Wei, H., Park, A. Y.-J., Kraus, M. S., Alcaraz, A., Chen, J., Chien, S., Cerione, R. A., Guan, J.-L. (2008). Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proc. Natl. Acad. Sci. USA 105: 6638-6643 [Abstract] [Full Text]  
  • Vultur, A., Buettner, R., Kowolik, C., Liang, W., Smith, D., Boschelli, F., Jove, R. (2008). SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Molecular Cancer Therapeutics 7: 1185-1194 [Abstract] [Full Text]  
  • Parsons, J. T., Slack-Davis, J., Tilghman, R., Roberts, W. G. (2008). Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention. Clin. Cancer Res. 14: 627-632 [Abstract] [Full Text]  
  • Hitchcock, I. S., Fox, N. E., Prevost, N., Sear, K., Shattil, S. J., Kaushansky, K. (2008). Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood 111: 596-604 [Abstract] [Full Text]  
  • Guo, W.-h., Wang, Y.-l. (2007). Retrograde Fluxes of Focal Adhesion Proteins in Response to Cell Migration and Mechanical Signals. Mol. Biol. Cell 18: 4519-4527 [Abstract] [Full Text]  
  • Jin, Y.-P., Korin, Y., Zhang, X., Jindra, P. T., Rozengurt, E., Reed, E. F. (2007). RNA Interference Elucidates the Role of Focal Adhesion Kinase in HLA Class I-Mediated Focal Adhesion Complex Formation and Proliferation in Human Endothelial Cells. J. Immunol. 178: 7911-7922 [Abstract] [Full Text]  
  • Thamilselvan, V., Craig, D. H., Basson, M. D. (2007). FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J. 21: 1730-1741 [Abstract] [Full Text]  
  • Walker, J. L., Wolff, I. M., Zhang, L., Menko, A. S. (2007). Activation of Src Kinases Signals Induction of Posterior Capsule Opacification. IOVS 48: 2214-2223 [Abstract] [Full Text]  
  • Di Florio, A., Capurso, G., Milione, M., Panzuto, F., Geremia, R., Fave, G. D., Sette, C. (2007). Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells. Endocr Relat Cancer 14: 111-124 [Abstract] [Full Text]  
  • Schober, M., Raghavan, S., Nikolova, M., Polak, L., Pasolli, H. A., Beggs, H. E., Reichardt, L. F., Fuchs, E. (2007). Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. JCB 176: 667-680 [Abstract] [Full Text]  
  • Quadri, S. K., Bhattacharya, J. (2007). Resealing of endothelial junctions by focal adhesion kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L334-L342 [Abstract] [Full Text]  
  • Hiscox, S., Morgan, L, Green, T., Nicholson, R. I (2006). Src as a therapeutic target in anti-hormone/anti-growth factor-resistant breast cancer. Endocr Relat Cancer 13: S53-S59 [Abstract] [Full Text]  
  • van Nimwegen, M. J., Huigsloot, M., Camier, A., Tijdens, I. B., van de Water, B. (2006). Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells. Mol. Pharmacol. 70: 1330-1339 [Abstract] [Full Text]  
  • Baudino, T. A., Carver, W., Giles, W., Borg, T. K. (2006). Cardiac fibroblasts: friend or foe?. Am. J. Physiol. Heart Circ. Physiol. 291: H1015-H1026 [Abstract] [Full Text]  
  • Gonzalez, L., Agullo-Ortuno, M. T., Garcia-Martinez, J. M., Calcabrini, A., Gamallo, C., Palacios, J., Aranda, A., Martin-Perez, J. (2006). Role of c-Src in Human MCF7 Breast Cancer Cell Tumorigenesis. J. Biol. Chem. 281: 20851-20864 [Abstract] [Full Text]  
  • Pirone, D. M., Liu, W. F., Ruiz, S. A., Gao, L., Raghavan, S., Lemmon, C. A., Romer, L. H., Chen, C. S. (2006). An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. JCB 174: 277-288 [Abstract] [Full Text]  
  • Ali, M. H., Mungai, P. T., Schumacker, P. T. (2006). Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants. Am. J. Physiol. Lung Cell. Mol. Physiol. 291: L38-L45 [Abstract] [Full Text]  
  • Bouchard, M. J., Wang, L., Schneider, R. J. (2006). Activation of Focal Adhesion Kinase by Hepatitis B Virus HBx Protein: Multiple Functions in Viral Replication. J. Virol. 80: 4406-4414 [Abstract] [Full Text]  
  • Chen, M., Chen, S. C., Pallen, C. J. (2006). Integrin-induced Tyrosine Phosphorylation of Protein-tyrosine Phosphatase-{alpha} Is Required for Cytoskeletal Reorganization and Cell Migration. J. Biol. Chem. 281: 11972-11980 [Abstract] [Full Text]  
  • Toruner, M., Fernandez-Zapico, M., Sha, J. J., Pham, L., Urrutia, R., Egan, L. J. (2006). Antianoikis Effect of Nuclear Factor-{kappa}B through Up-regulated Expression of Osteoprotegerin, BCL-2, and IAP-1. J. Biol. Chem. 281: 8686-8696 [Abstract] [Full Text]  
  • Romer, L. H., Birukov, K. G., Garcia, J. G.N. (2006). Focal Adhesions: Paradigm for a Signaling Nexus. Circ. Res. 98: 606-616 [Abstract] [Full Text]  
  • Kobayashi, T., Hino, S.-i., Oue, N., Asahara, T., Zollo, M., Yasui, W., Kikuchi, A. (2006). Glycogen Synthase Kinase 3 and h-prune Regulate Cell Migration by Modulating Focal Adhesions. Mol. Cell. Biol. 26: 898-911 [Abstract] [Full Text]  
  • Zhang, Z., Lin, S.-Y., Neel, B. G., Haimovich, B. (2006). Phosphorylated {alpha}-Actinin and Protein-tyrosine Phosphatase 1B Coregulate the Disassembly of the Focal Adhesion Kinase{middle dot}Src Complex and Promote Cell Migration. J. Biol. Chem. 281: 1746-1754 [Abstract] [Full Text]  
  • Moeller, M. L., Shi, Y., Reichardt, L. F., Ethell, I. M. (2006). EphB Receptors Regulate Dendritic Spine Morphogenesis through the Recruitment/Phosphorylation of Focal Adhesion Kinase and RhoA Activation. J. Biol. Chem. 281: 1587-1598 [Abstract] [Full Text]  
  • Maeda, M., Shintani, Y., Wheelock, M. J., Johnson, K. R. (2006). Src Activation Is Not Necessary for Transforming Growth Factor (TGF)-{beta}-mediated Epithelial to Mesenchymal Transitions (EMT) in Mammary Epithelial Cells: PP1 DIRECTLY INHIBITS TGF-{beta} RECEPTORS I AND II. J. Biol. Chem. 281: 59-68 [Abstract] [Full Text]  
  • Ceccarelli, D. F. J., Song, H. K., Poy, F., Schaller, M. D., Eck, M. J. (2006). Crystal Structure of the FERM Domain of Focal Adhesion Kinase. J. Biol. Chem. 281: 252-259 [Abstract] [Full Text]  
  • Tsutsumi, R., Takahashi, A., Azuma, T., Higashi, H., Hatakeyama, M. (2006). Focal Adhesion Kinase Is a Substrate and Downstream Effector of SHP-2 Complexed with Helicobacter pylori CagA. Mol. Cell. Biol. 26: 261-276 [Abstract] [Full Text]  
  • Mehta, D., Malik, A. B. (2006). Signaling Mechanisms Regulating Endothelial Permeability. Physiol. Rev. 86: 279-367 [Abstract] [Full Text]  
  • Payne, S. L., Fogelgren, B., Hess, A. R., Seftor, E. A., Wiley, E. L., Fong, S. F.T., Csiszar, K., Hendrix, M. J.C., Kirschmann, D. A. (2005). Lysyl Oxidase Regulates Breast Cancer Cell Migration and Adhesion through a Hydrogen Peroxide-Mediated Mechanism. Cancer Res. 65: 11429-11436 [Abstract] [Full Text]  
  • Samarel, A. M. (2005). Costameres, focal adhesions, and cardiomyocyte mechanotransduction. Am. J. Physiol. Heart Circ. Physiol. 289: H2291-H2301 [Abstract] [Full Text]  
  • Wee, J. L., Jackson, D. E. (2005). The Ig-ITIM superfamily member PECAM-1 regulates the "outside-in" signaling properties of integrin {alpha}IIb{beta}3 in platelets. Blood 106: 3816-3823 [Abstract] [Full Text]  
  • Benlimame, N., He, Q., Jie, S., Xiao, D., Xu, Y. J., Loignon, M., Schlaepfer, D. D., Alaoui-Jamali, M. A. (2005). FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion. JCB 171: 505-516 [Abstract] [Full Text]  
  • Grigera, P. R., Jeffery, E. D., Martin, K. H., Shabanowitz, J., Hunt, D. F., Parsons, J. T. (2005). FAK phosphorylation sites mapped by mass spectrometry. J. Cell Sci. 118: 4931-4935 [Full Text]  
  • Hamadi, A., Bouali, M., Dontenwill, M., Stoeckel, H., Takeda, K., Ronde, P. (2005). Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397. J. Cell Sci. 118: 4415-4425 [Abstract] [Full Text]  
  • Thamilselvan, V., Basson, M. D. (2005). The role of the cytoskeleton in differentially regulating pressure-mediated effects on malignant colonocyte focal adhesion signaling and cell adhesion. Carcinogenesis 26: 1687-1697 [Abstract] [Full Text]  
  • Salsmann, A., Schaffner-Reckinger, E., Kabile, F., Plancon, S., Kieffer, N. (2005). A New Functional Role of the Fibrinogen RGD Motif as the Molecular Switch That Selectively Triggers Integrin {alpha}IIb{beta}3-dependent RhoA Activation during Cell Spreading. J. Biol. Chem. 280: 33610-33619 [Abstract] [Full Text]  
  • Brown, M. C., Cary, L. A., Jamieson, J. S., Cooper, J. A., Turner, C. E. (2005). Src and FAK Kinases Cooperate to Phosphorylate Paxillin Kinase Linker, Stimulate Its Focal Adhesion Localization, and Regulate Cell Spreading and Protrusiveness. Mol. Biol. Cell 16: 4316-4328 [Abstract] [Full Text]  
  • Tilghman, R. W., Slack-Davis, J. K., Sergina, N., Martin, K. H., Iwanicki, M., Hershey, E. D., Beggs, H. E., Reichardt, L. F., Parsons, J. T. (2005). Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J. Cell Sci. 118: 2613-2623 [Abstract] [Full Text]  
  • Humphrey, D., Rajfur, Z., Vazquez, M. E., Scheswohl, D., Schaller, M. D., Jacobson, K., Imperiali, B. (2005). In Situ Photoactivation of a Caged Phosphotyrosine Peptide Derived from Focal Adhesion Kinase Temporarily Halts Lamellar Extension of Single Migrating Tumor Cells. J. Biol. Chem. 280: 22091-22101 [Abstract] [Full Text]  
  • Polykratis, A., Katsoris, P., Courty, J., Papadimitriou, E. (2005). Characterization of Heparin Affin Regulatory Peptide Signaling in Human Endothelial Cells. J. Biol. Chem. 280: 22454-22461 [Abstract] [Full Text]  
  • van Nimwegen, M. J., Verkoeijen, S., van Buren, L., Burg, D., van de Water, B. (2005). Requirement for Focal Adhesion Kinase in the Early Phase of Mammary Adenocarcinoma Lung Metastasis Formation. Cancer Res. 65: 4698-4706 [Abstract] [Full Text]  
  • Brabek, J., Constancio, S. S., Siesser, P. F., Shin, N.-Y., Pozzi, A., Hanks, S. K. (2005). Crk-Associated Substrate Tyrosine Phosphorylation Sites Are Critical for Invasion and Metastasis of Src-Transformed Cells. Mol Cancer Res 3: 307-315 [Abstract] [Full Text]  
  • Takahashi, M., Takahashi, F., Ui-Tei, K., Kojima, T., Saigo, K. (2005). Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila. Development 132: 2547-2559 [Abstract] [Full Text]  
  • Stoker, A. W (2005). Protein tyrosine phosphatases and signalling. J Endocrinol 185: 19-33 [Abstract] [Full Text]  
  • Yancy, S. L., Shelden, E. A., Gilmont, R. R., Welsh, M. J. (2005). Sodium Arsenite Exposure Alters Cell Migration, Focal Adhesion Localization and Decreases Tyrosine Phosphorylation of Focal Adhesion Kinase in H9C2 Myoblasts. Toxicol Sci 84: 278-286 [Abstract] [Full Text]  
  • Cohen, L. A., Guan, J.-L. (2005). Residues within the First Subdomain of the FERM-like Domain in Focal Adhesion Kinase Are Important in Its Regulation. J. Biol. Chem. 280: 8197-8207 [Abstract] [Full Text]  
  • Ding, Q., Grammer, J. R., Nelson, M. A., Guan, J.-L., Stewart, J. E. Jr., Gladson, C. L. (2005). p27Kip1 and Cyclin D1 Are Necessary for Focal Adhesion Kinase Regulation of Cell Cycle Progression in Glioblastoma Cells Propagated in Vitro and in Vivo in the Scid Mouse Brain. J. Biol. Chem. 280: 6802-6815 [Abstract] [Full Text]  
  • Brunton, V. G., Avizienyte, E., Fincham, V. J., Serrels, B., Metcalf, C. A. III, Sawyer, T. K., Frame, M. C. (2005). Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior. Cancer Res. 65: 1335-1342 [Abstract] [Full Text]  
  • Fonseca, P. M., Inoue, R. Y., Kobarg, C. B., Crosara-Alberto, D. P., Kobarg, J., Franchini, K. G. (2005). Targeting to C-Terminal Myosin Heavy Chain May Explain Mechanotransduction Involving Focal Adhesion Kinase in Cardiac Myocytes. Circ. Res. 96: 73-81 [Abstract] [Full Text]  
  • Iwahara, T., Akagi, T., Fujitsuka, Y., Hanafusa, H. (2004). CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas. Proc. Natl. Acad. Sci. USA 101: 17693-17698 [Abstract] [Full Text]  
  • Arya, R., Kedar, V., Hwang, J. R., McDonough, H., Li, H.-H., Taylor, J., Patterson, C. (2004). Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy. JCB 167: 1147-1159 [Abstract] [Full Text]  
  • Peng, X., Ueda, H., Zhou, H., Stokol, T., Shen, T.-L., Alcaraz, A., Nagy, T., Vassalli, J.-D., Guan, J.-L. (2004). Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovasc Res 64: 421-430 [Abstract] [Full Text]  
  • Orr, A. W., Pallero, M. A., Xiong, W.-C., Murphy-Ullrich, J. E. (2004). Thrombospondin Induces RhoA Inactivation through FAK-dependent Signaling to Stimulate Focal Adhesion Disassembly. J. Biol. Chem. 279: 48983-48992 [Abstract] [Full Text]  
  • Avraham, H. K., Jiang, S., Lee, T.-H., Prakash, O., Avraham, S. (2004). HIV-1 Tat-Mediated Effects on Focal Adhesion Assembly and Permeability in Brain Microvascular Endothelial Cells. J. Immunol. 173: 6228-6233 [Abstract] [Full Text]  
  • Zhang, Y., Lu, H., Dazin, P., Kapila, Y. (2004). Squamous Cell Carcinoma Cell Aggregates Escape Suspension-induced, p53-mediated Anoikis: FIBRONECTIN AND INTEGRIN {alpha}v MEDIATE SURVIVAL SIGNALS THROUGH FOCAL ADHESION KINASE. J. Biol. Chem. 279: 48342-48349 [Abstract] [Full Text]  
  • KUMAR, A., MURPHY, R., ROBINSON, P., WEI, L., BORIEK, A. M. (2004). Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-{kappa}B transcription factor. FASEB J. 18: 1524-1535 [Abstract] [Full Text]  
  • Westhoff, M. A., Serrels, B., Fincham, V. J., Frame, M. C., Carragher, N. O. (2004). Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling. Mol. Cell. Biol. 24: 8113-8133 [Abstract] [Full Text]  
  • Siu, M. K.Y., Cheng, C. Y. (2004). Extracellular Matrix: Recent Advances on Its Role in Junction Dynamics in the Seminiferous Epithelium During Spermatogenesis. Biol. Reprod. 71: 375-391 [Abstract] [Full Text]  
  • Boutahar, N., Guignandon, A., Vico, L., Lafage-Proust, M.-H. (2004). Mechanical Strain on Osteoblasts Activates Autophosphorylation of Focal Adhesion Kinase and Proline-rich Tyrosine Kinase 2 Tyrosine Sites Involved in ERK Activation. J. Biol. Chem. 279: 30588-30599 [Abstract] [Full Text]  
  • Giannone, G., Ronde, P., Gaire, M., Beaudouin, J., Haiech, J., Ellenberg, J., Takeda, K. (2004). Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions. J. Biol. Chem. 279: 28715-28723 [Abstract] [Full Text]  
  • Dunty, J. M., Gabarra-Niecko, V., King, M. L., Ceccarelli, D. F. J., Eck, M. J., Schaller, M. D. (2004). FERM Domain Interaction Promotes FAK Signaling. Mol. Cell. Biol. 24: 5353-5368 [Abstract] [Full Text]  
  • Duxbury, M. S., Ito, H., Ashley, S. W., Whang, E. E. (2004). CEACAM6 Cross-linking Induces Caveolin-1-dependent, Src-mediated Focal Adhesion Kinase Phosphorylation in BxPC3 Pancreatic Adenocarcinoma Cells. J. Biol. Chem. 279: 23176-23182 [Abstract] [Full Text]  
  • Ishizawar, R. C., Tice, D. A., Karaoli, T., Parsons, S. J. (2004). The C Terminus of c-Src Inhibits Breast Tumor Cell Growth by a Kinase-independent Mechanism. J. Biol. Chem. 279: 23773-23781 [Abstract] [Full Text]  
  • Itoh, S., Maeda, T., Shimada, M., Aishima, S.-i., Shirabe, K., Tanaka, S., Maehara, Y. (2004). Role of Expression of Focal Adhesion Kinase in Progression of Hepatocellular Carcinoma. Clin. Cancer Res. 10: 2812-2817 [Abstract] [Full Text]  
  • Sanders, M. A., Basson, M. D. (2004). Collagen IV regulates Caco-2 migration and ERK activation via {alpha}1{beta}1- and {alpha}2{beta}1-integrin-dependent Src kinase activation. Am. J. Physiol. Gastrointest. Liver Physiol. 286: G547-G557 [Abstract] [Full Text]  
  • Das, R., Mahabeleshwar, G. H., Kundu, G. C. (2004). Osteopontin Induces AP-1-mediated Secretion of Urokinase-type Plasminogen Activator through c-Src-dependent Epidermal Growth Factor Receptor Transactivation in Breast Cancer Cells. J. Biol. Chem. 279: 11051-11064 [Abstract] [Full Text]  
  • Stawowy, P., Kallisch, H., Veinot, J. P., Kilimnik, A., Prichett, W., Goetze, S., Seidah, N. G., Chretien, M., Fleck, E., Graf, K. (2004). Endoproteolytic Activation of {alpha}v Integrin by Proprotein Convertase PC5 Is Required for Vascular Smooth Muscle Cell Adhesion to Vitronectin and Integrin-Dependent Signaling. Circulation 109: 770-776 [Abstract] [Full Text]  
  • Di Stefano, P., Cabodi, S., Erba, E. B., Margaria, V., Bergatto, E., Giuffrida, M. G., Silengo, L., Tarone, G., Turco, E., Defilippi, P. (2004). p130Cas-associated Protein (p140Cap) as a New Tyrosine-phosphorylated Protein Involved in Cell Spreading. Mol. Biol. Cell 15: 787-800 [Abstract] [Full Text]  
  • Deo, D. D., Bazan, N. G., Hunt, J. D. (2004). Activation of Platelet-activating Factor Receptor-coupled G{alpha}q Leads to Stimulation of Src and Focal Adhesion Kinase via Two Separate Pathways in Human Umbilical Vein Endothelial Cells. J. Biol. Chem. 279: 3497-3508 [Abstract] [Full Text]  
  • Shibuya, K., Shirakawa, J., Kameyama, T., Honda, S.-i., Tahara-Hanaoka, S., Miyamoto, A., Onodera, M., Sumida, T., Nakauchi, H., Miyoshi, H., Shibuya, A. (2003). CD226 (DNAM-1) Is Involved in Lymphocyte Function-associated Antigen 1 Costimulatory Signal for Naive T Cell Differentiation and Proliferation. JEM 198: 1829-1839 [Abstract] [Full Text]  
  • Shima, T., Nada, S., Okada, M. (2003). Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts. Proc. Natl. Acad. Sci. USA 100: 14897-14902 [Abstract] [Full Text]  
  • Moissoglu, K., Gelman, I. H. (2003). v-Src Rescues Actin-based Cytoskeletal Architecture and Cell Motility and Induces Enhanced Anchorage Independence during Oncogenic Transformation of Focal Adhesion Kinase-null Fibroblasts. J. Biol. Chem. 278: 47946-47959 [Abstract] [Full Text]  
  • Huang, J., Asawa, T., Takato, T., Sakai, R. (2003). Cooperative Roles of Fyn and Cortactin in Cell Migration of Metastatic Murine Melanoma. J. Biol. Chem. 278: 48367-48376 [Abstract] [Full Text]  
  • Cooper, L. A., Shen, T.-L., Guan, J.-L. (2003). Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction. Mol. Cell. Biol. 23: 8030-8041 [Abstract] [Full Text]  
  • Naik, M. U., Naik, U. P. (2003). Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen. Blood 102: 3629-3636 [Abstract] [Full Text]  
  • Acosta, J. J., Munoz, R. M., Gonzalez, L., Subtil-Rodriguez, A., Dominguez-Caceres, M. A., Garcia-Martinez, J. M., Calcabrini, A., Lazaro-Trueba, I., Martin-Perez, J. (2003). Src Mediates Prolactin-Dependent Proliferation of T47D and MCF7 Cells via the Activation of Focal Adhesion Kinase/Erk1/2 and Phosphatidylinositol 3-Kinase Pathways. Mol. Endocrinol. 17: 2268-2282 [Abstract] [Full Text]  
  • Li, X., Yang, Y., Hu, Y., Dang, D., Regezi, J., Schmidt, B. L., Atakilit, A., Chen, B., Ellis, D., Ramos, D. M. (2003). {alpha}v{beta}6-Fyn Signaling Promotes Oral Cancer Progression. J. Biol. Chem. 278: 41646-41653 [Abstract] [Full Text]  
  • Shi, Q., Boettiger, D. (2003). A Novel Mode for Integrin-mediated Signaling: Tethering Is Required for Phosphorylation of FAK Y397. Mol. Biol. Cell 14: 4306-4315 [Abstract] [Full Text]  
  • Avraham, H. K., Lee, T.-H., Koh, Y., Kim, T.-A., Jiang, S., Sussman, M., Samarel, A. M., Avraham, S. (2003). Vascular Endothelial Growth Factor Regulates Focal Adhesion Assembly in Human Brain Microvascular Endothelial Cells through Activation of the Focal Adhesion Kinase and Related Adhesion Focal Tyrosine Kinase. J. Biol. Chem. 278: 36661-36668 [Abstract] [Full Text]  
  • Golubovskaya, V. M., Gross, S., Kaur, A. S., Wilson, R. I., Xu, L.-H., Yang, X. H., Cance, W. G. (2003). Simultaneous Inhibition of Focal Adhesion Kinase and Src Enhances Detachment and Apoptosis in Colon Cancer Cell Lines. Mol Cancer Res 1: 755-764 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»